Bryostatin Placebo-Controlled Trials
Indicate Cognitive Restoration Above
Baseline for Advanced Alzheimer’s Disease
in the Absence of Memantine1. Feb. 1, 2022 | |
AAIC Abstract July 26, 2021 | |
Activation of Protein Kinase C Isozymes for the Treatment of Dementias | |
Pharmacology of protein kinase C activators: Cognition-enhancing and antidementic therapeutics
Miao-Kun Sun, Daniel L. Alkon | |
PKC ε Activation Prevents Synaptic Loss, Aβ Elevation, and Cognitive Deficits in Alzheimer’s Disease Transgenic Mice
Jarin Hongpaisan, Miao-Kun Sun, and Daniel L. Alkon | |
PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer’s disease
Daniel L. Alkon, Miao-Kun Sun and Thomas J. Nelson | |
Neuroprotective versus tumorigenic protein kinase C activators
T.J. Nelson and D.L. Alkon | |
PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer’s disease
Daniel L. Alkon, Miao-Kun Sun and Thomas J. Nelson | |
Adduct formation in liquid chromatography-triple quadrupole mass spectrometric measurement of bryostatin 1
Thomas J. Nelson, Abhik Sen, Daniel L. Alkon, Miao-Kun Sun | |
PKCε Promotes HuD-Mediated Neprilysin mRNA Stability and Enhances Neprilysin-Induced Ab Degradation in Brain Neurons
Chol Seung Lim, Daniel L. Alkon | |
Bryostatin-1 Restores Hippocampal Synapses and Spatial Learning and Memory in Adult Fragile X Mice
Miao-Kun Sun, Jarin Hongpaisan, Chol Seung Lim, and Daniel L. Alkon
| |
PKC activation during training restores mushroom spine synapses and memory in the aged rat
Jarin Hongpaisan, Changqing Xu, Abhik Sen, Thomas J. Nelson, Daniel L. Alkon
| |
Synergistic effects of chronic bryostatin-1 and α-tocopherol on spatial learning and memory in rats
Miao-Kun Sun, Daniel L. Alkon | |
Postischemic PKC activation rescues retrograde and anterograde long-term memory
Miao-Kun Sun, Jarin Hongpaisan, and Daniel L. Alkon | |
Neuroprotective versus tumorigenic protein kinase C activators
T.J. Nelson and D.L. Alkon | |
Reduction of β-Amyloid Levels by Novel Protein Kinase Cε Activators
Thomas J. Nelson, Changhai Cui, Yuan Luo, and Daniel L. Alkon | |
A cellular model of Alzheimer’s disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts
Tapan K. Khana, Thomas J. Nelson, Vishal A. Verma, Paul A. Wender, and Daniel L. Alkon | |
Synergistic effects of chronic bryostatin-1 and α-tocopherol on spatial learning and memory in rats
Miao-Kun Sun, Daniel L. Alkon
| |
Analysis of long-term cognitive-enhancing effects of bryostatin-1 on the rabbit (Oryctolagus cuniculus) nictitating membrane response
Desheng Wang, Deya S. Darwish, Bernard G. Schreurs, and Daniel L. Alkon | |
PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer’s disease
Daniel L. Alkon, Miao-Kun Sun and Thomas J. Nelson | |
Protein synthesis required for long-term memory is induced by PKC activation on days before associative learning
Daniel L. Alkon, Herman Epstein, Alan Kuzirian, M. Catherine Bennett, and Thomas J. Nelson | |
Therapeutic effects of PKC activators in Alzheimer’s disease transgenic mice | |
Discrimination Learning Alters the Distribution of Protein Kinase C in the Hippocampus of Rats
James L. Olds, Stephanie Golski, Donna L. McPhie, David OKon, Mot-timer Mishkin and Daniel L. Alkonl | |
Classical conditioning induces long-term translocation of protein kinase C in rabbit hippocampal CAl cells (memory storage/membrane-associated protein kinase)
BARRY BANK, ANN DEWEER, ALAN M. KuZIRIAN, HOWARD RASMUSSEN, AND DANIEL L. ALKON | |
A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses
Aβ-induced biomarker abnormality on cultured fibroblasts
Tapan K. Khan, Thomas J. Nelson, Vishal A. Verma, Paul A. Wender, Daniel L. Alkon | |
The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades | |
PKC epsilon Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95 J Biol Chem. 5;291(32):16462-76, 2016 Abhik Sen, Jarin Hongpaisan, Desheng Wang, Thomas J. Nelson and Daniel L. Alkon | |
Rescue of Synaptic Phenotypes and Spatial Memory in Young Fragile X Mice. J. Pharmacol. Exp. Ther. 357: 300-310, 2016Miao-Kun Sun, Jarin Hongpaisan, and Daniel L. Alkon | |
ApoE4 and Aβ Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation Neuroscience 35(19): 7538-7551; doi: 10.1523 /JNEUROSCI. 0260-15.2015 Abhik Sen, Thomas J. Nelson and Daniel L. Alkon | |
Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase Cε. J Biol Chem 287(19), 15947-15948, 2012. Sen A, Alkon DL, Nelson TJ | |
PKCε Activation Prevents Synaptic Loss, Aβ Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice, Journal of Neuroscience, 31(2):630–643, 2011. Hongpaisan, J., Sun, MK, Alkon DL | |
Postischemic PKC activation rescues retrograde and anterograde long-term memory. (Proc Nat. Acad. Sci. USA) 106 (34): 14676–14680, 2009. Sun, MK, Hongpaisan, J, Alkon, DL | |
A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC. Proc Natl Acad Sci USA 104 (49): 19571-19576, 2007. Hongpaisan J, and Alkon DL | |
Towards universal therapeutics for memory disorders. Trends in Pharmacological Sciences, June 2015, Vol. 36, No. 6. Miao-Kun Sun, Thomas J. Nelson, and Daniel L. Alkon | |
PKC activator therapeutic for mild traumatic brain injury in mice. Neurobiology of Disease 41 (2011) 329–337. Ofer Zohar, Rotem Lavy, Xiaomei Zi, Thomas J. Nelson, Jarin Hongpaisan, Chaim G. Pick, D.L. Alkon | |